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tlr4 signaling  (MedChemExpress)


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    MedChemExpress tlr4 signaling
    <t>TLR4</t> inhibition supports zeolite-mediated reduction of LPS-induced NF-κB activation in THP-1 Dual cells. THP-1 Dual NF-κB reporter cells were pre-treated with the small-molecule TLR4 inhibitor TAK-242 (5 µM) for 1 h prior to stimulation with lipopolysaccharide (LPS) or combined clinoptilolite zeolite and LPS treatment conditions. DMSO (0.1%) was included as a vehicle control. Data are presented as mean ± SD. Statistical significance was determined using an unpaired Student’s t-test. ns, not significant.
    Tlr4 Signaling, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 46 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/receptor+4+tlr4+signaling/Toll-Like+Receptor+4+Antibody/pmc13468899-99-2-15
    Average 97 stars, based on 46 article reviews
    tlr4 signaling - by Bioz Stars, 2026-10
    97/100 stars

    Images

    1) Product Images from "Adsorption-mediated modulation of lipopolysaccharide bioactivity by clinoptilolite zeolite with in vitro immunomodulatory effects and in vivo safety evaluation"

    Article Title: Adsorption-mediated modulation of lipopolysaccharide bioactivity by clinoptilolite zeolite with in vitro immunomodulatory effects and in vivo safety evaluation

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2026.1818740

    TLR4 inhibition supports zeolite-mediated reduction of LPS-induced NF-κB activation in THP-1 Dual cells. THP-1 Dual NF-κB reporter cells were pre-treated with the small-molecule TLR4 inhibitor TAK-242 (5 µM) for 1 h prior to stimulation with lipopolysaccharide (LPS) or combined clinoptilolite zeolite and LPS treatment conditions. DMSO (0.1%) was included as a vehicle control. Data are presented as mean ± SD. Statistical significance was determined using an unpaired Student’s t-test. ns, not significant.
    Figure Legend Snippet: TLR4 inhibition supports zeolite-mediated reduction of LPS-induced NF-κB activation in THP-1 Dual cells. THP-1 Dual NF-κB reporter cells were pre-treated with the small-molecule TLR4 inhibitor TAK-242 (5 µM) for 1 h prior to stimulation with lipopolysaccharide (LPS) or combined clinoptilolite zeolite and LPS treatment conditions. DMSO (0.1%) was included as a vehicle control. Data are presented as mean ± SD. Statistical significance was determined using an unpaired Student’s t-test. ns, not significant.

    Techniques Used: Inhibition, Activation Assay, Control

    Related Articles

    other:

    Article Title: Clec7a promotes hippocampal microglial activation in rats with status epilepticus via inducing the TLR4/MyD88/NF-κB signaling pathway.
    Article Snippet: Microglial polarization imbalance between pro-inflammatory M1 and anti-inflammatory M2 phenotypes is a key mechanism in epilepsy-related neuroinflammation.. This study explores the role of C-type lectin domain containing 7A (Clec7a) in M1 microglial polarization in epilepsy.. An AAV-shClec7a was injected intra-hippocampally into Sprague-Dawley rats prior to induction of status epilepticus (SE) using lithium-pilocarpine.

    Quantitative RT-PCR:

    Article Title: Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages
    Article Snippet: .. For pretreatment of the inhibitor against Toll-like receptor 4 (TLR4) signaling, J774A.1 cells were seeded in a 6-well plate (3.0 × 10 5 J774A.1 cells/well) overnight and then pretreated for 6 h with the inhibitor Resatorvid (Res, 1 μM, MCE, NJ, USA) to suppress TLR4 signaling, followed by CB particles’ exposure at 10 μg/mL for another 24 h. After that, the cells were washed 3 times with PBS before collection for qRT-PCR analysis. ..



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    Image Search Results


    TLR4 inhibition supports zeolite-mediated reduction of LPS-induced NF-κB activation in THP-1 Dual cells. THP-1 Dual NF-κB reporter cells were pre-treated with the small-molecule TLR4 inhibitor TAK-242 (5 µM) for 1 h prior to stimulation with lipopolysaccharide (LPS) or combined clinoptilolite zeolite and LPS treatment conditions. DMSO (0.1%) was included as a vehicle control. Data are presented as mean ± SD. Statistical significance was determined using an unpaired Student’s t-test. ns, not significant.

    Journal: Frontiers in Immunology

    Article Title: Adsorption-mediated modulation of lipopolysaccharide bioactivity by clinoptilolite zeolite with in vitro immunomodulatory effects and in vivo safety evaluation

    doi: 10.3389/fimmu.2026.1818740

    Figure Lengend Snippet: TLR4 inhibition supports zeolite-mediated reduction of LPS-induced NF-κB activation in THP-1 Dual cells. THP-1 Dual NF-κB reporter cells were pre-treated with the small-molecule TLR4 inhibitor TAK-242 (5 µM) for 1 h prior to stimulation with lipopolysaccharide (LPS) or combined clinoptilolite zeolite and LPS treatment conditions. DMSO (0.1%) was included as a vehicle control. Data are presented as mean ± SD. Statistical significance was determined using an unpaired Student’s t-test. ns, not significant.

    Article Snippet: To inhibit TLR4 signaling, cells were pre-treated with the small-molecule TLR4 inhibitor TAK-242 ( ) (MedChemExpress, HY-11109) at a final concentration of 5 μM for 1 h prior to stimulation.

    Techniques: Inhibition, Activation Assay, Control

    Astaxanthin (AST) blocks HMGB1/TLR4 signaling transduction in allergic rhinitis (AR) mice and IL-13-stimulated HNEpCs. A ) Representative images of western blotting showing HMGB1, TLR4, Myd88, and (p-) NF-κB protein expression in mouse nasal mucosa. B-E ) Quantification of protein levels in mouse nasal mucosa. n = 5; *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. AR group or IL-13 group F ) CCK-8 assay showing changes in HNEpC viability following treatment with different concentrations of AST (0-100 μM) for 24 h. G ) CCK-8 assay showing the viability of HNEpCs treated with or without IL-13 and AST. H ) Western blotting of HMGB1 protein level in HNEpCs. I ) Representative images of western blotting showing HMGB1, TLR4, Myd88, and (p-) NF-κB protein expression in HNEpCs. J ) Quantification of protein levels in HNEpCs. n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. AR group or IL-13 group K , L ) Quantification of protein levels in HNEpCs. M ) Evaluation of SEAP activity in the culture medium n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. AR group or IL-13 group

    Journal: Central-European Journal of Immunology

    Article Title: Astaxanthin ameliorates allergic rhinitis via suppression of the HMGB1/TLR4 signaling pathway

    doi: 10.5114/ceji.2025.154608

    Figure Lengend Snippet: Astaxanthin (AST) blocks HMGB1/TLR4 signaling transduction in allergic rhinitis (AR) mice and IL-13-stimulated HNEpCs. A ) Representative images of western blotting showing HMGB1, TLR4, Myd88, and (p-) NF-κB protein expression in mouse nasal mucosa. B-E ) Quantification of protein levels in mouse nasal mucosa. n = 5; *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. AR group or IL-13 group F ) CCK-8 assay showing changes in HNEpC viability following treatment with different concentrations of AST (0-100 μM) for 24 h. G ) CCK-8 assay showing the viability of HNEpCs treated with or without IL-13 and AST. H ) Western blotting of HMGB1 protein level in HNEpCs. I ) Representative images of western blotting showing HMGB1, TLR4, Myd88, and (p-) NF-κB protein expression in HNEpCs. J ) Quantification of protein levels in HNEpCs. n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. AR group or IL-13 group K , L ) Quantification of protein levels in HNEpCs. M ) Evaluation of SEAP activity in the culture medium n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. AR group or IL-13 group

    Article Snippet: To inhibit TLR4 signaling transduction, cells were treated with 5 μM TAK-242 (a TLR4 inhibitor; MedChemExpress).

    Techniques: Transduction, Western Blot, Expressing, Control, CCK-8 Assay, Activity Assay

    Astaxanthin (AST) ameliorates inflammation and oxidative stress in IL-13-stimulated HNEpCs. A ) Detection of LDH release in the culture medium of HNEpCs treated with/without IL-13, AST (20 or 50 μM), or TAK-242 (a TLR4 inhibitor). B-D ) ELISA for determining levels of proinflammatory cytokines (IL-5, IL-6, TNF-α) in HNEpCs with indicated treatments. n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. IL-13 group E-G ) ELISA for determining levels of alarmins (IL-25, IL-33, TSLP) in HNEpCs with indicated treatments. H-J ) Measurement of ROS, MDA, and SOD levels in HNEpCs of each group. n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. IL-13 group

    Journal: Central-European Journal of Immunology

    Article Title: Astaxanthin ameliorates allergic rhinitis via suppression of the HMGB1/TLR4 signaling pathway

    doi: 10.5114/ceji.2025.154608

    Figure Lengend Snippet: Astaxanthin (AST) ameliorates inflammation and oxidative stress in IL-13-stimulated HNEpCs. A ) Detection of LDH release in the culture medium of HNEpCs treated with/without IL-13, AST (20 or 50 μM), or TAK-242 (a TLR4 inhibitor). B-D ) ELISA for determining levels of proinflammatory cytokines (IL-5, IL-6, TNF-α) in HNEpCs with indicated treatments. n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. IL-13 group E-G ) ELISA for determining levels of alarmins (IL-25, IL-33, TSLP) in HNEpCs with indicated treatments. H-J ) Measurement of ROS, MDA, and SOD levels in HNEpCs of each group. n = 3. *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. IL-13 group

    Article Snippet: To inhibit TLR4 signaling transduction, cells were treated with 5 μM TAK-242 (a TLR4 inhibitor; MedChemExpress).

    Techniques: Enzyme-linked Immunosorbent Assay, Control